Genetic Determinants of the Pharmacokinetic Variability of Rifampin in Malawian Adults with Pulmonary Tuberculosis

Variable exposure to antituberculosis (TB) drugs, partially driven by genetic factors, may be associated with poor clinical outcomes. Previous studies have suggested an influence of the SLCO1B1 locus on the plasma area under the concentration-time curve (AUC) of rifampin. We evaluated the contributi...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Sloan, Derek J., McCallum, Andrew D., Schipani, Alessandro, Egan, Deirdre, Mwandumba, Henry C., Ward, Steve A., Waterhouse, David, Banda, Gertrude, Allain, Theresa J., Owen, Andrew, Khoo, Saye H., Davies, Geraint R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Clinical Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487625/
https://ncbi.nlm.nih.gov/pubmed/28461315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00210-17
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