Genetic Determinants of the Pharmacokinetic Variability of Rifampin in Malawian Adults with Pulmonary Tuberculosis

Variable exposure to antituberculosis (TB) drugs, partially driven by genetic factors, may be associated with poor clinical outcomes. Previous studies have suggested an influence of the SLCO1B1 locus on the plasma area under the concentration-time curve (AUC) of rifampin. We evaluated the contributi...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Sloan, Derek J., McCallum, Andrew D., Schipani, Alessandro, Egan, Deirdre, Mwandumba, Henry C., Ward, Steve A., Waterhouse, David, Banda, Gertrude, Allain, Theresa J., Owen, Andrew, Khoo, Saye H., Davies, Geraint R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2017
Konular:
Clinical Therapeutics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487625/
https://ncbi.nlm.nih.gov/pubmed/28461315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00210-17
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