Genetic Determinants of the Pharmacokinetic Variability of Rifampin in Malawian Adults with Pulmonary Tuberculosis

Variable exposure to antituberculosis (TB) drugs, partially driven by genetic factors, may be associated with poor clinical outcomes. Previous studies have suggested an influence of the SLCO1B1 locus on the plasma area under the concentration-time curve (AUC) of rifampin. We evaluated the contributi...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Sloan, Derek J., McCallum, Andrew D., Schipani, Alessandro, Egan, Deirdre, Mwandumba, Henry C., Ward, Steve A., Waterhouse, David, Banda, Gertrude, Allain, Theresa J., Owen, Andrew, Khoo, Saye H., Davies, Geraint R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487625/
https://ncbi.nlm.nih.gov/pubmed/28461315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00210-17
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