Genetic Determinants of the Pharmacokinetic Variability of Rifampin in Malawian Adults with Pulmonary Tuberculosis

Variable exposure to antituberculosis (TB) drugs, partially driven by genetic factors, may be associated with poor clinical outcomes. Previous studies have suggested an influence of the SLCO1B1 locus on the plasma area under the concentration-time curve (AUC) of rifampin. We evaluated the contributi...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Sloan, Derek J., McCallum, Andrew D., Schipani, Alessandro, Egan, Deirdre, Mwandumba, Henry C., Ward, Steve A., Waterhouse, David, Banda, Gertrude, Allain, Theresa J., Owen, Andrew, Khoo, Saye H., Davies, Geraint R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Clinical Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487625/
https://ncbi.nlm.nih.gov/pubmed/28461315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00210-17
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