In Vitro Evaluation of Antileishmanial Activity of Computationally Screened Compounds against Ascorbate Peroxidase To Combat Amphotericin B Drug Resistance

In visceral leishmaniasis (VL), the host macrophages generate oxidative stress to destroy the pathogen, while Leishmania combats the harmful effect of radicals by redox homeostasis through its unique trypanothione cascade. Leishmania donovani ascorbate peroxidase (LdAPx) is a redox enzyme that regul...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Mansuri, Rani, Kumar, Ashish, Rana, Sindhuprava, Panthi, Bhavana, Ansari, M. Yousuf, Das, Sushmita, Dikhit, Manas Ranjan, Sahoo, Ganesh Chandra, Das, Pradeep
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487621/
https://ncbi.nlm.nih.gov/pubmed/28461317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02429-16
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