In Vitro Evaluation of Antileishmanial Activity of Computationally Screened Compounds against Ascorbate Peroxidase To Combat Amphotericin B Drug Resistance

In visceral leishmaniasis (VL), the host macrophages generate oxidative stress to destroy the pathogen, while Leishmania combats the harmful effect of radicals by redox homeostasis through its unique trypanothione cascade. Leishmania donovani ascorbate peroxidase (LdAPx) is a redox enzyme that regul...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Mansuri, Rani, Kumar, Ashish, Rana, Sindhuprava, Panthi, Bhavana, Ansari, M. Yousuf, Das, Sushmita, Dikhit, Manas Ranjan, Sahoo, Ganesh Chandra, Das, Pradeep
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487621/
https://ncbi.nlm.nih.gov/pubmed/28461317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02429-16
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