In Vitro Evaluation of Antileishmanial Activity of Computationally Screened Compounds against Ascorbate Peroxidase To Combat Amphotericin B Drug Resistance

In visceral leishmaniasis (VL), the host macrophages generate oxidative stress to destroy the pathogen, while Leishmania combats the harmful effect of radicals by redox homeostasis through its unique trypanothione cascade. Leishmania donovani ascorbate peroxidase (LdAPx) is a redox enzyme that regul...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Antimicrob Agents Chemother
Egile Nagusiak: Mansuri, Rani, Kumar, Ashish, Rana, Sindhuprava, Panthi, Bhavana, Ansari, M. Yousuf, Das, Sushmita, Dikhit, Manas Ranjan, Sahoo, Ganesh Chandra, Das, Pradeep
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2017
Gaiak:
Mechanisms of Resistance
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487621/
https://ncbi.nlm.nih.gov/pubmed/28461317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02429-16
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