In Vitro Evaluation of Antileishmanial Activity of Computationally Screened Compounds against Ascorbate Peroxidase To Combat Amphotericin B Drug Resistance

In visceral leishmaniasis (VL), the host macrophages generate oxidative stress to destroy the pathogen, while Leishmania combats the harmful effect of radicals by redox homeostasis through its unique trypanothione cascade. Leishmania donovani ascorbate peroxidase (LdAPx) is a redox enzyme that regul...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Mansuri, Rani, Kumar, Ashish, Rana, Sindhuprava, Panthi, Bhavana, Ansari, M. Yousuf, Das, Sushmita, Dikhit, Manas Ranjan, Sahoo, Ganesh Chandra, Das, Pradeep
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487621/
https://ncbi.nlm.nih.gov/pubmed/28461317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02429-16
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