SUCNR1-mediated chemotaxis of macrophages aggravates obesity-induced inflammation and diabetes

AIMS/HYPOTHESIS: Obesity induces macrophages to drive inflammation in adipose tissue, a crucial step towards the development of type 2 diabetes. The tricarboxylic acid (TCA) cycle intermediate succinate is released from cells under metabolic stress and has recently emerged as a metabolic signal indu...

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Veröffentlicht in:Diabetologia
Hauptverfasser: van Diepen, Janna A., Robben, Joris H., Hooiveld, Guido J., Carmone, Claudia, Alsady, Mohammad, Boutens, Lily, Bekkenkamp-Grovenstein, Melissa, Hijmans, Anneke, Engelke, Udo F. H., Wevers, Ron A., Netea, Mihai G., Tack, Cees J., Stienstra, Rinke, Deen, Peter M. T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487589/
https://ncbi.nlm.nih.gov/pubmed/28382382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-017-4261-z
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