Immune Escape Variants of H9N2 Influenza Viruses Containing Deletions at the Hemagglutinin Receptor Binding Site Retain Fitness In Vivo and Display Enhanced Zoonotic Characteristics

H9N2 avian influenza viruses are enzootic in poultry across Asia and North Africa, where they pose a threat to human health as both zoonotic agents and potential pandemic candidates. Poultry vaccination against H9N2 viruses has been employed in many regions; however, vaccine effectiveness is frequen...

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Vydáno v:J Virol
Hlavní autoři: Peacock, Thomas P., Benton, Donald J., James, Joe, Sadeyen, Jean-Remy, Chang, Pengxiang, Sealy, Joshua E., Bryant, Juliet E., Martin, Stephen R., Shelton, Holly, Barclay, Wendy S., Iqbal, Munir
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487547/
https://ncbi.nlm.nih.gov/pubmed/28468875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00218-17
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