Immune Escape Variants of H9N2 Influenza Viruses Containing Deletions at the Hemagglutinin Receptor Binding Site Retain Fitness In Vivo and Display Enhanced Zoonotic Characteristics

H9N2 avian influenza viruses are enzootic in poultry across Asia and North Africa, where they pose a threat to human health as both zoonotic agents and potential pandemic candidates. Poultry vaccination against H9N2 viruses has been employed in many regions; however, vaccine effectiveness is frequen...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Peacock, Thomas P., Benton, Donald J., James, Joe, Sadeyen, Jean-Remy, Chang, Pengxiang, Sealy, Joshua E., Bryant, Juliet E., Martin, Stephen R., Shelton, Holly, Barclay, Wendy S., Iqbal, Munir
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487547/
https://ncbi.nlm.nih.gov/pubmed/28468875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00218-17
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