dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication

Enterovirus 71 (EV-A71) causes hand, foot and mouth disease in young children and infants, but can also cause severe neurological complications or even death. The double-stranded RNA (dsRNA)-dependent protein kinase R (PKR), an interferon-induced antiviral protein, phosphorylates the regulatory α-su...

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Bibliographic Details
Published in:Front Cell Infect Microbiol
Main Authors: Chang, Yu-Hsiu, Lau, Kean Seng, Kuo, Rei-Lin, Horng, Jim-Tong
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487429/
https://ncbi.nlm.nih.gov/pubmed/28702377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2017.00284
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