Alloantigen-Induced Regulatory T Cells Generated in Presence of Vitamin C Display Enhanced Stability of Foxp3 Expression and Promote Skin Allograft Acceptance

Regulatory T cells (Tregs) are critical for the maintenance of immune homeostasis and self-tolerance and can be therapeutically used for prevention of unwanted immune responses such as allotransplant rejection. Tregs are characterized by expression of the transcription factor Foxp3, and recent work...

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Udgivet i:Front Immunol
Main Authors: Nikolouli, Eirini, Hardtke-Wolenski, Matthias, Hapke, Martin, Beckstette, Michael, Geffers, Robert, Floess, Stefan, Jaeckel, Elmar, Huehn, Jochen
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487376/
https://ncbi.nlm.nih.gov/pubmed/28702031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00748
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