Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3(+) and Foxp3(−) T cells

Costimulatory signals by CD28 are critical for thymic regulatory T-cell (Treg) development. To determine the functional relevance of CD28 for peripheral Treg post thymic selection, we crossed the widely used Forkhead box protein 3 (Foxp3)-CreYFP mice to mice bearing a conditional Cd28 allele. Treg-s...

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Detalhes bibliográficos
Publicado no:Immunol Cell Biol
Main Authors: Franckaert, Dean, Dooley, James, Roos, Evelyne, Floess, Stefan, Huehn, Jochen, Luche, Herve, Fehling, Hans Joerg, Liston, Adrian, Linterman, Michelle A, Schlenner, Susan M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407013/
https://ncbi.nlm.nih.gov/pubmed/25533288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2014.108
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