Differential Protein Acetylation Assists Import of Excess SOD2 into Mitochondria and Mediates SOD2 Aggregation Associated with Cardiac Hypertrophy in the Murine SOD2-tg Heart

SOD2 is the primary antioxidant enzyme neutralizing (•)O(2)(−) in mitochondria. Cardiac-specific SOD2 overexpression (SOD2-tg) induces supernormal function and cardiac hypertrophy in the mouse heart. However, the reductive stress imposed by SOD2 overexpression results in protein aggregation of SOD2...

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Veröffentlicht in:Free Radic Biol Med
Hauptverfasser: Zhang, Liwen, Chen, Chwen-Lih, Kang, Patrick T., Jin, Zhicheng, Chen, Yeong-Renn
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487267/
https://ncbi.nlm.nih.gov/pubmed/28433661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.04.022
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