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Impairment of pH Gradient and Membrane Potential Mediates Redox Dysfunction in the Mitochondria of the Post-ischemic Heart
The mitochondrial electrochemical gradient (Δp), which comprises the pH gradient (ΔpH) and the membrane potential (ΔΨ), is crucial in controlling energy transduction. During myocardial ischemia and reperfusion (IR), mitochondrial dysfunction mediates superoxide ((•)O(2)(−)) and H(2)O(2) overproducti...
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| Published in: | Basic Res Cardiol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5495109/ https://ncbi.nlm.nih.gov/pubmed/28508960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-017-0626-1 |
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