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Impairment of pH Gradient and Membrane Potential Mediates Redox Dysfunction in the Mitochondria of the Post-ischemic Heart
The mitochondrial electrochemical gradient (Δp), which comprises the pH gradient (ΔpH) and the membrane potential (ΔΨ), is crucial in controlling energy transduction. During myocardial ischemia and reperfusion (IR), mitochondrial dysfunction mediates superoxide ((•)O(2)(−)) and H(2)O(2) overproducti...
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| Publicado en: | Basic Res Cardiol |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5495109/ https://ncbi.nlm.nih.gov/pubmed/28508960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-017-0626-1 |
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