Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity

Vulnerability of motoneurons in amyotrophic lateral sclerosis (ALS) arises from a combination of several mechanisms, including protein misfolding and aggregation, mitochondrial dysfunction and oxidative damage. Protein aggregates are found in motoneurons in models for ALS linked to a mutation in the...

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Huvudupphovsmän: Ferri, Alberto, Fiorenzo, Paolo, Nencini, Monica, Cozzolino, Mauro, Pesaresi, Maria Grazia, Valle, Cristiana, Sepe, Sara, Moreno, Sandra, Carrì, Maria Teresa
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2010
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298854/
https://ncbi.nlm.nih.gov/pubmed/20829229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq383
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