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Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity
Vulnerability of motoneurons in amyotrophic lateral sclerosis (ALS) arises from a combination of several mechanisms, including protein misfolding and aggregation, mitochondrial dysfunction and oxidative damage. Protein aggregates are found in motoneurons in models for ALS linked to a mutation in the...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3298854/ https://ncbi.nlm.nih.gov/pubmed/20829229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq383 |
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