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Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes

Biologic treatment of T1D typically results in transient stabilization of C-peptide levels (a surrogate for endogenous insulin secretion) in some patients, followed by progression at the same rate as in untreated control groups. Here, we used integrated systems biology and flow cytometry approaches...

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Bibliografske podrobnosti
izdano v:Sci Immunol
Main Authors: Long, S. Alice, Thorpe, Jerill, DeBerg, Hannah A., Gersuk, Vivian, Eddy, James, Harris, Kristina M., Ehlers, Mario, Herold, Kevan C., Nepom, Gerald T., Linsley, Peter S.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486405/
https://ncbi.nlm.nih.gov/pubmed/28664195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aai7793
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