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Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes

Biologic treatment of T1D typically results in transient stabilization of C-peptide levels (a surrogate for endogenous insulin secretion) in some patients, followed by progression at the same rate as in untreated control groups. Here, we used integrated systems biology and flow cytometry approaches...

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Podrobná bibliografie
Vydáno v:Sci Immunol
Hlavní autoři: Long, S. Alice, Thorpe, Jerill, DeBerg, Hannah A., Gersuk, Vivian, Eddy, James, Harris, Kristina M., Ehlers, Mario, Herold, Kevan C., Nepom, Gerald T., Linsley, Peter S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486405/
https://ncbi.nlm.nih.gov/pubmed/28664195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aai7793
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