An Amyloidogenic Sequence at the N-Terminus of the Androgen Receptor Impacts Polyglutamine Aggregation

The human androgen receptor (AR) is a ligand inducible transcription factor that harbors an amino terminal domain (AR-NTD) with a ligand-independent activation function. AR-NTD is intrinsically disordered and displays aggregation properties conferred by the presence of a poly-glutamine (polyQ) seque...

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Vydáno v:Biomolecules
Hlavní autoři: Oppong, Emmanuel, Stier, Gunter, Gaal, Miriam, Seeger, Rebecca, Stoeck, Melanie, Delsuc, Marc-André, Cato, Andrew C. B., Kieffer, Bruno
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485733/
https://ncbi.nlm.nih.gov/pubmed/28629183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom7020044
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