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Large ring-forming alkylations provide facile access to composite macrocycles
Macrocyclic compounds have potential to enable drug discovery for protein targets with extended, solvent-exposed binding sites. Crystallographic structures of peptides bound at such sites show strong surface complementarity and frequent aromatic side-chain contacts. In an effort to capture these fea...
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| Veröffentlicht in: | Chem Sci |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Royal Society of Chemistry
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5485560/ https://ncbi.nlm.nih.gov/pubmed/28694951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc03848g |
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