PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D

Activating mutations in PIK3CA, the gene encoding phosphoinositide-(3)-kinase α (PI3Kα), are frequently found in estrogen receptor (ER)–positive breast cancer. PI3Kα inhibitors, now in late-stage clinical development, elicit a robust compensatory increase in ER-dependent transcription that limits th...

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Publicado no:Science
Main Authors: Toska, Eneda, Osmanbeyoglu, Hatice U., Castel, Pau, Chan, Carmen, Hendrickson, Ronald C., Elkabets, Moshe, Dickler, Maura N., Scaltriti, Maurizio, Leslie, Christina S., Armstrong, Scott A., Baselga, José
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485411/
https://ncbi.nlm.nih.gov/pubmed/28336670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah6893
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