Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design

The interactions between the tumor suppressor protein p21(WAF1) and the cyclin-dependent kinase (CDK) complexes and with proliferating cell nuclear antigen (PCNA) regulate and coordinate the processes of cell-cycle progression and DNA replication. We present the x-ray crystal structure of PCNA compl...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kontopidis, George, Wu, Su-Ying, Zheleva, Daniella I., Taylor, Paul, McInnes, Campbell, Lane, David P., Fischer, Peter M., Walkinshaw, Malcolm D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2005
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC548533/
https://ncbi.nlm.nih.gov/pubmed/15681588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406540102
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