In vivo IL-4 prevents allo-antigen driven CD8(+) CTL development

IL-4 has been shown to suppress acute graft vs. host disease (GVHD) in irradiated hosts. Here we evaluated whether IL-4 suppresses acute GVHD in the un-irradiated parent-into-F1 GVHD model with relevance to renal allograft rejection. IL-4 completely suppressed CD8 CTL when administered with donor ce...

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Publicado en:Clin Immunol
Main Authors: Via, Charles S., Soloviova, Kateryna, Puliaiev, Maksym, Puliav, Roman, Puliaeva, Irina, Morris, Suzanne C., Finkelman, Fred D.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484589/
https://ncbi.nlm.nih.gov/pubmed/28359782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2017.03.008
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