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Donor CD8 T Cells and IFN-γ Are Critical for Sex-Based Differences in Donor CD4 T Cell Engraftment and Lupus-Like Phenotype in Short-Term Chronic Graft-Versus-Host Disease Mice

The transfer of unfractionated DBA/2J (DBA) splenocytes into B6D2F(1) (DBA → F(1)) mice results in greater donor CD4 T cell engraftment in females at day 14 that persists long-term and mediates greater female lupus-like renal disease. Although donor CD8 T cells have no demonstrated role in lupus pat...

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Main Authors: Foster, Anthony D., Soloviova, Kateryna, Puliaeva, Irina, Puliaiev, Maksym, Puliaev, Roman, Finkelman, Fred, Via, Charles S.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215299/
https://ncbi.nlm.nih.gov/pubmed/21531893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001074
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