Donor CD8 T cell activation is critical for greater renal disease severity in female chronic graft-vs-host mice and is associated with increased splenic ICOS(hi) host CD4 T cells and IL-21 expression

Lupus-like renal disease in DBA/2-into-F1 (DBA→F1) mice is driven by donor CD4 T cells and is more severe in females. Donor CD8 T cells have no known role. As expected, we observed that females receiving unfractionated DBA splenocytes (CD8 intact→F1) exhibited greater clinical and histological sever...

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Autores principales: Foster, Anthony D., Haas, Mark, Puliaeva, Irina, Soloviova, Kateryna, Puliaev, Roman, Via, Charles S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898507/
https://ncbi.nlm.nih.gov/pubmed/20451460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2010.01.005
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