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Donor CD8 T cell activation is critical for greater renal disease severity in female chronic graft-vs-host mice and is associated with increased splenic ICOS(hi) host CD4 T cells and IL-21 expression
Lupus-like renal disease in DBA/2-into-F1 (DBA→F1) mice is driven by donor CD4 T cells and is more severe in females. Donor CD8 T cells have no known role. As expected, we observed that females receiving unfractionated DBA splenocytes (CD8 intact→F1) exhibited greater clinical and histological sever...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2898507/ https://ncbi.nlm.nih.gov/pubmed/20451460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2010.01.005 |
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