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A slow conformational switch in the BMAL1 transactivation domain modulates circadian rhythms
The C-terminal transactivation domain (TAD) of BMAL1 (Brain and muscle ARNT-like 1) is a regulatory hub for transcriptional coactivators and repressors that compete for binding and consequently contributes to period determination of the mammalian circadian clock. Here, we report the discovery of two...
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| Publicat a: | Mol Cell |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5484534/ https://ncbi.nlm.nih.gov/pubmed/28506462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.04.011 |
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