A slow conformational switch in the BMAL1 transactivation domain modulates circadian rhythms

The C-terminal transactivation domain (TAD) of BMAL1 (Brain and muscle ARNT-like 1) is a regulatory hub for transcriptional coactivators and repressors that compete for binding and consequently contributes to period determination of the mammalian circadian clock. Here, we report the discovery of two...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Gustafson, Chelsea L., Parsley, Nicole C., Asimgil, Hande, Lee, Hsiau-Wei, Ahlbach, Christopher, Michael, Alicia K., Xu, Haiyan, Williams, Owen L., Davis, Tara L., Liu, Andrew C., Partch, Carrie L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484534/
https://ncbi.nlm.nih.gov/pubmed/28506462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.04.011
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