Loss of prion protein induces a primed state of type I interferon-responsive genes

The cellular prion protein (PrP(C)) has been extensively studied because of its pivotal role in prion diseases; however, its functions remain incompletely understood. A unique line of goats has been identified that carries a nonsense mutation that abolishes synthesis of PrP(C). In these animals, the...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Malachin, Giulia, Reiten, Malin R., Salvesen, Øyvind, Aanes, Håvard, Kamstra, Jorke H., Skovgaard, Kerstin, Heegaard, Peter M. H., Ersdal, Cecilie, Espenes, Arild, Tranulis, Michael A., Bakkebø, Maren K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484497/
https://ncbi.nlm.nih.gov/pubmed/28651013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179881
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