LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface

BACKGROUND: The cellular prion protein (PrP(C)) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goats naturally devoid of PrP(C) (PRNP (Ter/Ter)) provides a novel model for s...

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Bibliographic Details
Published in:J Neuroinflammation
Main Authors: Salvesen, Ø., Reiten, M. R., Espenes, A., Bakkebø, M. K., Tranulis, M. A., Ersdal, C.
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441080/
https://ncbi.nlm.nih.gov/pubmed/28532450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0879-5
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