Single-cell molecular analysis defines therapy response and immunophenotype of stem cell subpopulations in CML

Understanding leukemia heterogeneity is critical for the development of curative treatments as the failure to eliminate therapy-persistent leukemic stem cells (LSCs) may result in disease relapse. Here we have combined high-throughput immunophenotypic screens with large-scale single-cell gene expres...

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Vydáno v:Blood
Hlavní autoři: Warfvinge, Rebecca, Geironson, Linda, Sommarin, Mikael N. E., Lang, Stefan, Karlsson, Christine, Roschupkina, Teona, Stenke, Leif, Stentoft, Jesper, Olsson-Strömberg, Ulla, Hjorth-Hansen, Henrik, Mustjoki, Satu, Soneji, Shamit, Richter, Johan, Karlsson, Göran
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2017
Témata:
Hematopoiesis and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484462/
https://ncbi.nlm.nih.gov/pubmed/28122740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-07-728873
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