Single-cell molecular analysis defines therapy response and immunophenotype of stem cell subpopulations in CML

Understanding leukemia heterogeneity is critical for the development of curative treatments as the failure to eliminate therapy-persistent leukemic stem cells (LSCs) may result in disease relapse. Here we have combined high-throughput immunophenotypic screens with large-scale single-cell gene expres...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Warfvinge, Rebecca, Geironson, Linda, Sommarin, Mikael N. E., Lang, Stefan, Karlsson, Christine, Roschupkina, Teona, Stenke, Leif, Stentoft, Jesper, Olsson-Strömberg, Ulla, Hjorth-Hansen, Henrik, Mustjoki, Satu, Soneji, Shamit, Richter, Johan, Karlsson, Göran
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2017
Matèries:
Hematopoiesis and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484462/
https://ncbi.nlm.nih.gov/pubmed/28122740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-07-728873
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