Single-cell molecular analysis defines therapy response and immunophenotype of stem cell subpopulations in CML

Understanding leukemia heterogeneity is critical for the development of curative treatments as the failure to eliminate therapy-persistent leukemic stem cells (LSCs) may result in disease relapse. Here we have combined high-throughput immunophenotypic screens with large-scale single-cell gene expres...

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Bibliographic Details
Published in:Blood
Main Authors: Warfvinge, Rebecca, Geironson, Linda, Sommarin, Mikael N. E., Lang, Stefan, Karlsson, Christine, Roschupkina, Teona, Stenke, Leif, Stentoft, Jesper, Olsson-Strömberg, Ulla, Hjorth-Hansen, Henrik, Mustjoki, Satu, Soneji, Shamit, Richter, Johan, Karlsson, Göran
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2017
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484462/
https://ncbi.nlm.nih.gov/pubmed/28122740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-07-728873
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