Single-cell molecular analysis defines therapy response and immunophenotype of stem cell subpopulations in CML

Understanding leukemia heterogeneity is critical for the development of curative treatments as the failure to eliminate therapy-persistent leukemic stem cells (LSCs) may result in disease relapse. Here we have combined high-throughput immunophenotypic screens with large-scale single-cell gene expres...

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Bibliografiska uppgifter
I publikationen:Blood
Huvudupphovsmän: Warfvinge, Rebecca, Geironson, Linda, Sommarin, Mikael N. E., Lang, Stefan, Karlsson, Christine, Roschupkina, Teona, Stenke, Leif, Stentoft, Jesper, Olsson-Strömberg, Ulla, Hjorth-Hansen, Henrik, Mustjoki, Satu, Soneji, Shamit, Richter, Johan, Karlsson, Göran
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2017
Ämnen:
Hematopoiesis and Stem Cells
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484462/
https://ncbi.nlm.nih.gov/pubmed/28122740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-07-728873
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