Recombinant Modified Vaccinia Virus Ankara Expressing the Spike Glycoprotein of Severe Acute Respiratory Syndrome Coronavirus Induces Protective Neutralizing Antibodies Primarily Targeting the Receptor Binding Region

Immunization with a killed or inactivated viral vaccine provides significant protection in animals against challenge with certain corresponding pathogenic coronaviruses (CoVs). However, the promise of this approach in humans is hampered by serious concerns over the risk of leaking live severe acute...

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Veröffentlicht in:J Virol
Hauptverfasser: Chen, Zhiwei, Zhang, Linqi, Qin, Chuan, Ba, Lei, Yi, Christopher E., Zhang, Fengwen, Wei, Qiang, He, Tian, Yu, Wenjie, Yu, Jian, Gao, Hong, Tu, Xinming, Gettie, Agegnehu, Farzan, Michael, Yuen, Kwok-yung, Ho, David D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2005
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC548443/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15708987/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.79.5.2678-2688.2005
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