Recombinant Modified Vaccinia Virus Ankara Expressing the Spike Glycoprotein of Severe Acute Respiratory Syndrome Coronavirus Induces Protective Neutralizing Antibodies Primarily Targeting the Receptor Binding Region

Immunization with a killed or inactivated viral vaccine provides significant protection in animals against challenge with certain corresponding pathogenic coronaviruses (CoVs). However, the promise of this approach in humans is hampered by serious concerns over the risk of leaking live severe acute...

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Detalles Bibliográficos
Autores principales: Chen, Zhiwei, Zhang, Linqi, Qin, Chuan, Ba, Lei, Yi, Christopher E., Zhang, Fengwen, Wei, Qiang, He, Tian, Yu, Wenjie, Yu, Jian, Gao, Hong, Tu, Xinming, Gettie, Agegnehu, Farzan, Michael, Yuen, Kwok-yung, Ho, David D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC548443/
https://ncbi.nlm.nih.gov/pubmed/15708987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.5.2678-2688.2005
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