The Coiled-Coil Domain of the Adenovirus Type 5 Protein IX Is Dispensable for Capsid Incorporation and Thermostability

The 14.4-kDa hexon-associated protein IX (pIX) acts as a cement in the capsids of primate adenoviruses and confers a thermostable phenotype. Here we show that deletion of amino acids 100 to 114 of adenovirus type 5 pIX, which eliminates the conserved coiled-coil domain, impairs its capacity to self-...

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Autors principals: Vellinga, Jort, van den Wollenberg, Diana J. M., van der Heijdt, Stephanie, Rabelink, Martijn J. W. E., Hoeben, Rob C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Gene Delivery
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC548437/
https://ncbi.nlm.nih.gov/pubmed/15709043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.5.3206-3210.2005
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