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A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA

2-Hydroxy-2-deoxyadenosine triphosphate (2-OH-dATP), generated by the oxidation of dATP, can be misincorporated by DNA polymerases opposite guanine in template DNA during DNA replication, thus causing spontaneous mutagenesis. We demonstrated that mouse MUTYH (mMUTYH) has a DNA glycosylase activity e...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Ushijima, Yasuhiro, Tominaga, Yohei, Miura, Tomofumi, Tsuchimoto, Daisuke, Sakumi, Kunihiko, Nakabeppu, Yusaku
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2005
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC548358/
https://ncbi.nlm.nih.gov/pubmed/15681617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki214
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