MUTYH prevents OGG1 or APEX1 from inappropriately processing its substrate or reaction product with its C-terminal domain

MutY homolog (MUTYH) excises adenine opposite 8-oxoguanine (8-oxoG) in DNA, thus preventing occurrence of G:C to T:A transversion. In cell-free extract prepared from the thymocytes of wild type but not MUTYH-null mice, adenine opposite 8-oxoG in DNA was excised by MUTYH, however, the generated apuri...

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Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Tominaga, Yohei, Ushijima, Yasuhiro, Tsuchimoto, Daisuke, Mishima, Masaki, Shirakawa, Masahiro, Hirano, Seiki, Sakumi, Kunihiko, Nakabeppu, Yusaku
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2004
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434447/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15199168/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh642
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