MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis

8-Oxoguanine (8-oxoG), a major oxidative base lesion, is highly accumulated in Alzheimer’s disease (AD) brains during the pathogenic process. MTH1 hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, thereby avoiding 8-oxo-dG incorporation into DNA. 8-OxoG DNA glycosylase-1 (OGG1) excises 8-oxoG paired with cytosin...

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Publicat a:Sci Rep
Autors principals: Oka, Sugako, Leon, Julio, Sakumi, Kunihiko, Abolhassani, Nona, Sheng, Zijing, Tsuchimoto, Daisuke, LaFerla, Frank M., Nakabeppu, Yusaku
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988129/
https://ncbi.nlm.nih.gov/pubmed/33758207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84640-9
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