8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

8-Oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species, is associated with carcinogenesis and neurodegeneration. Although the mechanism by which 8-oxoG causes carcinogenesis is well understood, the mechanism by which it causes neurodegeneration is unknown. Here, we report that...

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Main Authors: Sheng, Zijing, Oka, Sugako, Tsuchimoto, Daisuke, Abolhassani, Nona, Nomaru, Hiroko, Sakumi, Kunihiko, Yamada, Hidetaka, Nakabeppu, Yusaku
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533558/
https://ncbi.nlm.nih.gov/pubmed/23143307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65053
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