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8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair
8-Oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species, is associated with carcinogenesis and neurodegeneration. Although the mechanism by which 8-oxoG causes carcinogenesis is well understood, the mechanism by which it causes neurodegeneration is unknown. Here, we report that...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3533558/ https://ncbi.nlm.nih.gov/pubmed/23143307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65053 |
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