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Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs
Oxidative base lesions, such as 8-oxoguanine (8-oxoG), accumulate in nuclear and mitochondrial DNAs under oxidative stress, resulting in cell death. However, it is not known which form of DNA is involved, whether nuclear or mitochondrial, nor is it known how the death order is executed. We establish...
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| Main Authors: | , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Nature Publishing Group
2008
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234344/ https://ncbi.nlm.nih.gov/pubmed/18188152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601975 |
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