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Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs

Oxidative base lesions, such as 8-oxoguanine (8-oxoG), accumulate in nuclear and mitochondrial DNAs under oxidative stress, resulting in cell death. However, it is not known which form of DNA is involved, whether nuclear or mitochondrial, nor is it known how the death order is executed. We establish...

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Detalhes bibliográficos
Main Authors: Oka, Sugako, Ohno, Mizuki, Tsuchimoto, Daisuke, Sakumi, Kunihiko, Furuichi, Masato, Nakabeppu, Yusaku
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234344/
https://ncbi.nlm.nih.gov/pubmed/18188152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601975
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