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Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs

Oxidative base lesions, such as 8-oxoguanine (8-oxoG), accumulate in nuclear and mitochondrial DNAs under oxidative stress, resulting in cell death. However, it is not known which form of DNA is involved, whether nuclear or mitochondrial, nor is it known how the death order is executed. We establish...

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Detaylı Bibliyografya
Asıl Yazarlar: Oka, Sugako, Ohno, Mizuki, Tsuchimoto, Daisuke, Sakumi, Kunihiko, Furuichi, Masato, Nakabeppu, Yusaku
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2008
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234344/
https://ncbi.nlm.nih.gov/pubmed/18188152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601975
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