NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals

Mammalian inosine triphosphatase encoded by ITPA gene hydrolyzes ITP and dITP to monophosphates, avoiding their deleterious effects. Itpa(−) mice exhibited perinatal lethality, and significantly higher levels of inosine in cellular RNA and deoxyinosine in nuclear DNA were detected in Itpa(−) embryos...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Abolhassani, Nona, Iyama, Teruaki, Tsuchimoto, Daisuke, Sakumi, Kunihiko, Ohno, Mizuki, Behmanesh, Mehrdad, Nakabeppu, Yusaku
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2010
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875033/
https://ncbi.nlm.nih.gov/pubmed/20081199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1250
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares