NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals

Mammalian inosine triphosphatase encoded by ITPA gene hydrolyzes ITP and dITP to monophosphates, avoiding their deleterious effects. Itpa(−) mice exhibited perinatal lethality, and significantly higher levels of inosine in cellular RNA and deoxyinosine in nuclear DNA were detected in Itpa(−) embryos...

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Autors principals: Abolhassani, Nona, Iyama, Teruaki, Tsuchimoto, Daisuke, Sakumi, Kunihiko, Ohno, Mizuki, Behmanesh, Mehrdad, Nakabeppu, Yusaku
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875033/
https://ncbi.nlm.nih.gov/pubmed/20081199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1250
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