NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals

Mammalian inosine triphosphatase encoded by ITPA gene hydrolyzes ITP and dITP to monophosphates, avoiding their deleterious effects. Itpa(−) mice exhibited perinatal lethality, and significantly higher levels of inosine in cellular RNA and deoxyinosine in nuclear DNA were detected in Itpa(−) embryos...

Full description

Saved in:
Bibliographic Details
Main Authors: Abolhassani, Nona, Iyama, Teruaki, Tsuchimoto, Daisuke, Sakumi, Kunihiko, Ohno, Mizuki, Behmanesh, Mehrdad, Nakabeppu, Yusaku
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875033/
https://ncbi.nlm.nih.gov/pubmed/20081199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1250
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items