8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

8-Oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species, is associated with carcinogenesis and neurodegeneration. Although the mechanism by which 8-oxoG causes carcinogenesis is well understood, the mechanism by which it causes neurodegeneration is unknown. Here, we report that...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Sheng, Zijing, Oka, Sugako, Tsuchimoto, Daisuke, Abolhassani, Nona, Nomaru, Hiroko, Sakumi, Kunihiko, Yamada, Hidetaka, Nakabeppu, Yusaku
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2012
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533558/
https://ncbi.nlm.nih.gov/pubmed/23143307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65053
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi