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MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death

p53-regulated caspase-independent cell death has been implicated in suppression of tumorigenesis, however, the regulating mechanisms are poorly understood. We previously reported that 8-oxoguanine (8-oxoG) accumulation in nuclear DNA (nDNA) and mitochondrial DNA triggers two distinct caspase-indepen...

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Bibliografiske detaljer
Udgivet i:Oncogenesis
Main Authors: Oka, S, Leon, J, Tsuchimoto, D, Sakumi, K, Nakabeppu, Y
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216901/
https://ncbi.nlm.nih.gov/pubmed/25310643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2014.35
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