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MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death
p53-regulated caspase-independent cell death has been implicated in suppression of tumorigenesis, however, the regulating mechanisms are poorly understood. We previously reported that 8-oxoguanine (8-oxoG) accumulation in nuclear DNA (nDNA) and mitochondrial DNA triggers two distinct caspase-indepen...
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| Udgivet i: | Oncogenesis |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4216901/ https://ncbi.nlm.nih.gov/pubmed/25310643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2014.35 |
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