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Time-dependent PPARγ Modulation of HIF-1α Signaling in Hypoxic Pulmonary Artery Smooth Muscle Cells

BACKGROUND: Pathogenesis of pulmonary hypertension is complex and involves activation of the transcription factor, hypoxia-inducible factor-1 (HIF-1) that shifts cellular metabolism from aerobic respiration to glycolysis, in part, by increasing the expression of its downstream target pyruvate dehydr...

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Dades bibliogràfiques
Publicat a:Am J Med Sci
Autors principals: Blum, Justine I., Bijli, Kaiser M., Murphy, Tamara C., Kleinhenz, Jennifer M., Hart, C. Michael
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5483378/
https://ncbi.nlm.nih.gov/pubmed/27432037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.amjms.2016.03.019
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