Hypoxia downregulates PPARγ via an ERK 1/2-NF-κB-Nox4- dependent mechanism in human pulmonary artery smooth muscle cells

The ligand-activated transcription factor, peroxisome proliferator-activated receptor gamma (PPARγ), regulates metabolism, cell proliferation, and inflammation. Pulmonary hypertension (PH) is associated with reduced PPARγ expression, and hypoxia exposure regimens that cause PH reduce PPARγ expressio...

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Bibliographic Details
Main Authors:	Lu, Xianghuai, Bijli, Kaiser M., Ramirez, Allan, Murphy, Tamara C., Kleinhenz, Jennifer, Hart, C. Michael
Format:	Artigo
Language:	Inglês
Published:	2013
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3729594/ https://ncbi.nlm.nih.gov/pubmed/23684777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.05.013
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Hypoxia downregulates PPARγ via an ERK 1/2-NF-κB-Nox4- dependent mechanism in human pulmonary artery smooth muscle cells

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