The PPARγ ligand rosiglitazone attenuates hypoxia-induced endothelin signaling in vitro and in vivo

Peroxisome proliferator-activated receptor (PPAR) γ activation attenuates hypoxia-induced pulmonary hypertension (PH) in mice. The current study examined the hypothesis that PPARγ attenuates hypoxia-induced endothelin-1 (ET-1) signaling to mediate these therapeutic effects. To test this hypothesis,...

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Main Authors: Kang, Bum-Yong, Kleinhenz, Jennifer M., Murphy, Tamara C., Hart, C. Michael
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2011
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233829/
https://ncbi.nlm.nih.gov/pubmed/21926265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00195.2011
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