Peroxisome Proliferator–Activated Receptor γ and microRNA 98 in Hypoxia-Induced Endothelin-1 Signaling

Endothelin-1 (ET-1) plays a critical role in endothelial dysfunction and contributes to the pathogenesis of pulmonary hypertension (PH). We hypothesized that peroxisome proliferator–activated receptor γ (PPARγ) stimulates microRNAs that inhibit ET-1 and pulmonary artery endothelial cell (PAEC) proli...

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Vydáno v:Am J Respir Cell Mol Biol
Hlavní autoři: Kang, Bum-Yong, Park, Kathy K., Kleinhenz, Jennifer M., Murphy, Tamara C., Green, David E., Bijli, Kaiser M., Yeligar, Samantha M., Carthan, Kristal A., Searles, Charles D., Sutliff, Roy L., Hart, C. Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742924/
https://ncbi.nlm.nih.gov/pubmed/26098770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0337OC
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