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PPARγ regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-κB

NADPH oxidases are a major source of superoxide production in the vasculature. The constitutively active Nox4 subunit, which is selectively upregulated in the lungs of human subjects and experimental animals with pulmonary hypertension, is highly expressed in vascular wall cells. We demonstrated tha...

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Bibliografski detalji
Glavni autori: Lu, Xianghuai, Murphy, Tamara C., Nanes, Mark S., Hart, C. Michael
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957423/
https://ncbi.nlm.nih.gov/pubmed/20622120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00090.2010
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